Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies

The process for the detection of monoclonal gammopathies (MGs) is highly complex. To obtain an accurate diagnosis, diagnostic data must be compiled from several areas of the laboratory (eg, total protein, immunoglobulin levels, gel or capillary electrophoreses patterns).

“Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies,” establishes recommendations that pathologists and clinicians can implement to better manage testing and improve the accurate diagnoses of patients with MGs.

• Guideline Status: Active
• Published online ahead of print: August 4, 2021
• Originally published: May 2022
• Collaborators: American Association for Clinical Chemistry, American Society for Clinical Pathology, American Society of Hematology, and International Myeloma Working Group

The following tools and resources are available to help implement the guideline:

• Summary of Recommendations
• Methodology Supplement (Supplemental Digital Content)
• Infographic
• Algorithm