The Accreditation Council for Graduate Medical Education defines cytopathology as the subspecialty of pathology dedicated to the study and diagnosis of human disease manifested in tissues at a cellular level.

Cytopathologists are unique in that their work covers all organ systems and requires an extremely specific skillset. Cytopathologists interact frequently with clinicians, and may also interact with patients and perform on-site evaluations, as the specialty allows for fast, accurate diagnoses using minimally invasive techniques. Standardized reporting enables quality assurance and informatics.

Cytopathologists have the chance to see a wide range of organ systems, including the ability to perform fine-needle aspirations (FNA), and can be used for screening, diagnostic, therapeutic, and prognostic biomarker testing. This subspecialty also allows pathologists to use small amounts of patient tissue/specimen to make a diagnosis or to triage appropriate testing, and it provides opportunities for direct patient care. Cytopathologists can focus on their area of interest, but it’s imperative that they keep themselves updated by constantly improving their research and education.

Frequently Asked Questions

Perhaps due in part to the closure of cytotechnology schools across the US, employment challenges can include a shortage of staff—cytologists, cytology preparatory staff, and particularly cytotechnologists. Additionally, changes in cervical cancer screening guidelines and the possibility of reduced gynecological cytology volumes may have an impact. However, since cytopathology deals with both gynecologic and non-gynecologic samples, and with the availability of tissue for ancillary testing, many labs have dedicated cytopathology services, which can make finding a job a little easier.

The standard fellowship is one year.

It depends on where you’re practicing. For some, cytopathology requires on-call time, but usually not after hours or on the weekends. Some may need to perform Rapid On-Site Evaluation (ROSE) to assess the adequacy of FNA samples procured by an endoscopist (pulmonologist and gastroenterologist) as well as the interventional radiologist. Most cytopathologists’ on-call assignments are limited to weekday work hours and are over the weekend only for emergencies.

The case volume for cytopathologists varies widely, with some labs seeing 25–40 cases per day and others up to 50–100. There can be approximately 8,000 non-gyn and 35,000 gyn cases over the course of a year (not all gyn cases are reviewed by pathologists, just the abnormal). Ancillary testing, such as IHC and molecular testing, is common on cell block material that accompanies many cases and can include selecting cases for molecular/PD-L1 testing, correlating with HPV results, and sending out for thyroid molecular testing. Some labs prefer to run tests on corresponding paraffin-embedded tissue. Overall, there is a great deal of variability in case volume and ancillary testing depending on the place of employment.

Cytopathologists interact with a variety of specialties. In fact, cytopathologists at any given time interact with any and all specialties—including, but not limited to, pulmonologists, otolaryngologists, interventional radiologists, hematopathologists, surgeons, oncologists, endocrinologists, gastroenterologists, urologists, and obstetric/gynecological specialists.

Cytopathology pairs well with many pathology subspecialties, particularly genitourinary, gynecologic, otolaryngologic, and gastrointestinal—basically anything except autopsy. So that also includes thoracic, head and neck, molecular, general surgical pathology, hematopathology, and soft tissue. Additionally, due to FNA cases and Pap smear cases in cytology, it can also pair with breast and pancreatic pathology.

Cytopathologists can interact with patients through pathologist-performed FNA clinics where history is taken and FNA is performed. Some labs have integrated FNA clinics with ENT physician clinics where they perform FNAs at the clinician's request. During ROSE, patients are awake and can interact with the cytopathologist. However, not all cytopathologists interact with patients, and many have no interaction at all.

  • Cytopathology Topic Center

    Resources and educational material from the CAP in the field of cytopathology.

  • Cytopathology Committee

    Participating in a council or committee is a great way to be a part of the CAP community.

  • Subspecialty Spotlight Series

    Hosted by the CAP Residents Forum, this unique event offers medical students and pathology residents the opportunity to hear from experts representing a range of subspecialties.

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