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Video Resources
The following videos are from a presentation by CAP Oncology Committee members given at the Association for Molecular Pathology (AMP) 2022 Annual Meeting & Expo, "Proficiency Testing Data to Improve the Performance of Your Molecular Laboratory."
Manuscripts
The CAP Molecular Oncology Committee publishes manuscripts about laboratory quality and performance utilizing data derived from proficiency testing supported by the committee. The following manuscripts were authored by members of the Molecular Oncology Committee.
2024
- Genomic Reporting Practices Across 5 Molecular Disciplines: A Study From the College of American Pathologists
Archives of Pathology & Laboratory Medicine 2024
Larissa V. Furtado, Annette S. Kim, Ann M. Moyer, Joel T. Moncur, Rena R. Xian, Angshumoy Roy, Avni B. Santani, Yassmine Akkari, Karl V. Voelkerding, Rhona J. Souers, Jaimie Halley, Glenn E. Palomaki - Current Laboratory Testing Practices for Mismatch Repair Deficiency and Microsatellite Instability Testing: A Survey-Based Review of Current Laboratory Practices
American Journal of Clinical Pathology 2024
Amy L. Austin, Russell R. Broaddus, Rhona J. Souers, Megan E Kane, Ravindra Kolhe, Dylan V. Miller, Joel T. Moncur, Shakti Ramkissoon, Laura J. Tafe, Dimitri G. Trembath, Rondell P. Graham - Laboratory Considerations for Releasing Next-Generation Sequencing Data to Patients
Archives of Pathology & Laboratory Medicine 2024
Ann Moyer, Eric Loo, Evan Cadoff, Eric Konnick, Helena Duncan, Jaimie Halley, Katherine Hermina, Patricia Vasalos, Joel T. Moncur, Sophia Yohe - Applicability of Existing College of American Pathologists Accreditation Requirements to Clinical Implementation of Machine Learning–Based Methods in Molecular Oncology Testing
Archives of Pathology and Laboratory Medicine 2024
Larissa V. Furtado, Kenji Ikemura, Cagla Y. Benkli, Joel T. Moncur, Richard S. P. Huang, Ahmet Zehir, Katherine Stellato, Patricia Vasalos, Navid Sadri, Carlos J. Suarez
Previous Manuscripts
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- SPOT/Dx Pilot Reanalysis and College of American Pathologists Proficiency Testing for KRAS and NRAS Demonstrate Excellent Laboratory Performance
Archives of Pathology & Laboratory Medicine 2023
Ahmet Zehir, Valentina Nardi, Eric Q. Konnick, Christina M. Lockwood, Thomas A. Long, Nikoletta Sidiropoulos, Rhona J. Souers, Patricia Vasalos, Neal I. Lindeman, Joel T. Moncur - RNA Sequencing for Solid Tumor Fusion Gene Detection: Proficiency Testing Practice and Performance Comparison
Archives of Pathology & Laboratory Medicine 2023
Julia A. Bridge, Kevin C. Halling, Joel T. Moncur, Rhona J. Souers, Meera R. Hameed, Helen Fernandes, Angshumoy Roy, Lea Surrey, Laura J. Tafe, Patricia Vasalos, Dolores H. Lopez-Terrada - In Silico Approaches to Proficiency Testing: Considerations for Continued Feasibility
Journal of Molecular Diagnostics 2023
Ian S. Hagemann, Ahmet Zehir, Carlos J. Suarez, Larissa V. Furtado, Jaimie Halley, Megan Kane, Nicole Mot, Patricia Vasalos, Joel T. Moncur, Eric Q. Konnick
- Current Laboratory Testing Practices for
Assessment of ERBB2/HER2 in Endometrial Serous Carcinoma and Colorectal
Carcinoma
Archives of Pathology & Laboratory Medicine 2022
Ian S. Hagemann, Julia A. Bridge, Laura J. Tafe, Meera R. Hameed, Joel T. Moncur, Andrew M. Bellizzi, Michelle Dolan, Patricia Vasalos, Megan E. Kane, Rhona J. Souers, Anna Yemelyanova - Clinical Laboratory Testing Practices in
Diffuse Gliomas Prior to Publication of 2021 World Health Organization Classification of Central Nervous
System Tumors
Archives of Pathology & Laboratory Medicine 2022
Shakti H. Ramkissoon, Helen Fernandes, Dolores H. Lopez-Terrada, Meera R. Hameed, Dimitri G. Trembath, Julia A. Bridge, Neal I. Lindeman, Rhona J. Souers, Patricia Vasalos, Daniel J. Brat, Joel T. Moncur - Clinical Testing for Tumor Cell-Free DNA:
College of American Pathologists' Proficiency Programs Reveal Practice Trends
Archives of Pathology & Laboratory Medicine 2022
Kelly A. Devereaux, Rhona J. Souers, Jason D. Merker, Neal I. Lindeman, Rondell P. Graham, Meera R. Hameed, Patricia Vasalos, Joel T. Moncur, Christina M. Lockwood, Rena R. Xian - Four-Year Laboratory Performance of the
First College of American Pathologists In Silico Next-Generation Sequencing Bioinformatics Proficiency
Testing Surveys
Archives of Pathology & Laboratory Medicine 2022
Larissa V. Furtado, Rhona J. Souers, Patricia Vasalos, Jaimie G. Halley, Dara L. Aisner, Rakesh Nagarajan, Karl V. Voelkerding, Jason D. Merker, Eric Q. Konnick - Most Frequently Cited Accreditation Inspection Deficiencies for Clinical Molecular Oncology
Testing Laboratories and Opportunities for Improvement
Archives of Pathology & Laboratory Medicine 2022
Authors: Nikoletta Sidiropoulos, Sarah K. Daley, Marian Briggs, Helen Fernandes, Christina M. Lockwood, Amer Z. Mahmoud, Jason D. Merker, Patricia Vasalos, Lynnette M. Wielgos, Joel T. Moncur, Daniel H. Farkas - Neoplastic Cellularity Assessment in
Molecular Testing: A Multi-institutional Practice Survey and Performance Challenge Identifies a Need for
Standardization
Archives of Pathology & Laboratory Medicine 2022
Authors: Kelly A. Devereaux, Rhona J. Souers, Rondell P. Graham, Bryce P. Portier, Lea F. Surrey, Anna Yemelyanova, Patricia Vasalos, Dimitri G. Trembath, Joel T. Moncur - Tiered Somatic Variant Classification
Adoption Has Increased Worldwide With Some Practice Differences Based on Location and Institutional Setting:
A Study From the College of American Pathologists Molecular Oncology
Committee
Archives of Pathology & Laboratory Medicine 2022
Authors: Frido K. Bruehl, Annette S. Kim, Marilyn M. Li, Neal I. Lindeman, Joel T. Moncur, Rhona J. Souers, Patricia Vasalos, Karl V. Voelkerding, Rena R. Xian, Lea F. Surrey
- Next-Generation Sequencing Somatic and Germline Assay Troubleshooting Guide Derived From Proficiency Testing Data
Archives of Pathology & Laboratory Medicine 2021
Authors: Valentina Nardi, Karen D. Tsuchiya, Annette S. Kim, Lora J. H. Bean, Jaimie G. Halley, Thomas A. Long, Szabolcs Szelinger, Patricia Vasalos, John A. Thorson, Ann M. Moyer, Joel T. Moncur - An Overview of Characteristics of Clinical Next-Generation Sequencing–Based Testing for Hematologic Malignancies
Archives of Pathology & Laboratory Medicine 2021
Authors: Bing M. Zhang, Alissa Keegan, Peng Li, Neal I. Lindeman, Rakesh Nagarajan, Mark J. Routbort, Patricia Vasalos, Annette S. Kim, Jason D. Merker
- Proficiency Testing of Standardized Samples Shows High Interlaboratory Agreement for Clinical Next-Generation Sequencing–Based Hematologic Malignancy Assays With Survey Material–Specific Differences in Variant Frequencies
Archives of Pathology & Laboratory Medicine 1 August 2020; 144 (8): 959–966
Authors: Alissa Keegan, Julia A. Bridge, Neal I. Lindeman, Thomas A. Long, Jason D. Merker, Joel T. Moncur, Nathan D. Montgomery, Rakesh Nagarajan, Paul G. Rothberg, Mark J. Routbort, Patricia Vasalos, Rena Xian, Annette S. Kim - Comparative Performance of High-Risk Human Papillomavirus RNA and DNA In Situ Hybridization on College of American Pathologists Proficiency Tests
Archives of Pathology & Laboratory Medicine 1 March 2020; 144 (3): 344–349
Authors: Elaine S. Keung, Rhona J. Souers, Julia A. Bridge, William C. Faquin, Rondell P. Graham, Meera R. Hameed, James S. Lewis, Jason D. Merker, Patricia Vasalos, Joel T. Moncur
- Performance Comparison of Different Analytic Methods in Proficiency Testing for Mutations in the BRAF, EGFR, and KRAS Genes: A Study of the College of American Pathologists Molecular Oncology Committee
Archives of Pathology & Laboratory Medicine 1 October 2019; 143 (10): 1203–1211
Authors: Joel T. Moncur, Angela N. Bartley, Julia A. Bridge, Suzanne Kamel-Reid, Alexander J. Lazar, Neal I. Lindeman, Thomas A. Long, Jason D. Merker, Alex J. Rai, David L. Rimm, Paul G. Rothberg, Patricia Vasalos, Annette S. Kim - Next-Generation Sequencing (NGS) Methods Show Superior or Equivalent Performance to Non-NGS Methods on BRAF, EGFR, and KRAS Proficiency Testing Samples
Archives of Pathology & Laboratory Medicine 1 August 2019; 143 (8): 980–984
Authors: Lea F. Surrey, Fredrick D. Oakley, Jason D. Merker, Thomas A. Long, Patricia Vasalos, Joel T. Moncur, Annette S. Kim - Proficiency Testing of Standardized Samples Shows Very High Interlaboratory Agreement for Clinical Next-Generation Sequencing–Based Oncology Assays
Archives of Pathology & Laboratory Medicine 1 April 2019; 143 (4): 463–471
Authors: Jason D. Merker, Kelly Devereaux, A. John Iafrate, Suzanne Kamel-Reid, Annette S. Kim, Joel T. Moncur, Stephen B. Montgomery, Rakesh Nagarajan, Bryce P. Portier, Mark J. Routbort, Craig Smail, Lea F. Surrey, Patricia Vasalos, Alexander J. Lazar, Neal I. Lindeman
- Comparative Performance of Breast Cancer Human Epidermal Growth Factor Receptor 2 Fluorescence In Situ Hybridization and Brightfield In Situ Hybridization on College of American Pathologists Proficiency Tests
Archives of Pathology & Laboratory Medicine 1 October 2018; 142 (10): 1254–1259
Authors: Katherine B. Geiersbach, Julia A. Bridge, Michelle Dolan, Lawrence J. Jennings, Diane L. Persons, Rhona J. Souers, Karen D. Tsuchiya, Patricia H. Vasalos, Joel T. Moncur - Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review
Archives of Pathology & Laboratory Medicine 1 October 2018; 142 (10): 1242–1253
Authors: Jason D. Merker, Geoffrey R. Oxnard, Carolyn Compton, Maximilian Diehn, Patricia Hurley, Alexander J. Lazar, Neal Lindeman, Christina M. Lockwood, Alex J. Rai, Richard L. Schilsky, Apostolia M. Tsimberidou, Patricia Vasalos, Brooke L. Billman, Thomas K. Oliver, Suanna S. Bruinooge, Daniel F. Hayes, Nicholas C. Turner - Comparison of Laboratory-Developed Tests and FDA-Approved Assays for BRAF, EGFR, and KRAS Testing.
JAMA Oncol. June 2018; 4(6):838–841.
Authors: Annette Kim, Angela N. Bartley, Julia A. Bridge, Suzanne Kamel-Reid, Alexander J. Lazar, Neal I. Lindeman, Thomas A. Long, Jason D. Merker, Alex J. Rai, David L. Rimm, Paul G. Rothberg, Patricia Vasalos, Joel T. Moncur - Worldwide Frequency of Commonly Detected EGFR Mutations
Archives of Pathology & Laboratory Medicine 1 February 2018; 142 (2): 163–167
Authors: Rondell P. Graham, Amanda L. Treece, Neal I. Lindeman, Patricia Vasalos, Mu Shan, Lawrence J. Jennings, David L. Rimm
- A Window Into Clinical Next-Generation Sequencing–Based Oncology Testing Practices
Archives of Pathology & Laboratory Medicine 1 December 2017; 141 (12): 1679–1685
Authors: Rakesh Nagarajan, Angela N. Bartley, Julia A. Bridge, Lawrence J. Jennings, Suzanne Kamel-Reid, Annette Kim, Alexander J. Lazar, Neal I. Lindeman, Joel Moncur, Alex J. Rai, Mark J. Routbort, Patricia Vasalos, Jason D. Merker - Reporting Results of Molecular Tests: A Retrospective Examination of BRAF Mutation Reporting
Archives of Pathology & Laboratory Medicine 1 May 2017; 141 (5): 658–665
Authors: Amanda L. Treece, Margaret L. Gulley, Patricia Vasalos, Cherie Paquette, Neal I. Lindeman, Lawrence J. Jennings, Angela N. Bartley
- Summary of Microsatellite Instability Test Results From Laboratories Participating in Proficiency Surveys: Proficiency Survey Results From 2005 to 2012
Archives of Pathology & Laboratory Medicine 1 March 2014; 138 (3): 363–370
Authors: Theresa A. Boyle, Julia A. Bridge, Linda M. Sabatini, Jan A. Nowak, Patricia Vasalos, Lawrence J. Jennings, Kevin C. Halling, and the College of American Pathologists Molecular Oncology Committee - A Prospective, Multi-Institutional Diagnostic Trial to Determine Pathologist Accuracy in Estimation of Percentage of Malignant Cells
Archives of Pathology & Laboratory Medicine 1 November 2013; 137 (11): 1545–1549
Authors: Hollis Viray, Kevin Li, Thomas A. Long, Patricia Vasalos, Julia A. Bridge, Lawrence J. Jennings, Kevin C. Halling, Meera Hameed, David L. Rimm